Table 5.
Scenario analyses
| Area of uncertainty | Base case | Scenarios |
|---|---|---|
| Perspective | Healthcare system |
UK government Societal |
| Discount rate | 3.5% for costs and outcomes | 1.5% for costs and outcomes |
| Health state definition | Average eye | Best-seeing eye |
| Source of baseline characteristics | Phase III trial | Natural history data |
| Transition probability matrices in initial phase | Crossover data excluded | Crossover data included |
| Duration of treatment effect | 40 years |
20 years 30 years Lifetime |
| Multistate survival model distribution | Weibull |
Exponential Gompertz Log-logistic Log-normal |
| Utility values | EQ-5D-5L | HUI3 |