Table 1.
Patient demographic and clinical characteristics during the 60-month pre-diagnosis period
| Total (n = 11,793) | Short delay (n = 4446) | Intermediate delay (n = 3179) | Long delay (n = 4168) | Short versus intermediate p value |
Short versus long p value |
Intermediate versus long p value |
|
|---|---|---|---|---|---|---|---|
| Age, mean (SD) | 39.3 (7.4) | 39.8 (7.0) | 38.9 (7.8) | 38.9 (7.6) | < 0.001 | < 0.001 | 0.940 |
| Region, n (%) | 0.747 | 0.025 | 0.188 | ||||
| Northeast | 850 (7.2) | 291 (6.6) | 218 (6.9) | 341 (8.2) | |||
| Midwest | 3301 (28.0) | 1263 (28.4) | 885 (27.8) | 1153 (27.7) | |||
| South | 5892 (50.0) | 2246 (50.5) | 1591 (50.1) | 2055 (49.3) | |||
| West | 1748 (14.8) | 646 (14.5) | 485 (15.3) | 617 (14.8) | |||
| Other | 2 (0.0) | 0 (0.0) | 0 (0.0) | 2 (0.1) | |||
| Length of diagnostic delay (days), mean (SD) | 763.9 (631.0) | 90.2 (103.6) | 733.4 (213.7) | 1505.9 (212.0) | < 0.001 | < 0.001 | < 0.001 |
| Presence of endometriosis symptoms, n (%) | |||||||
| Dysmenorrhea | 6132 (52.0) | 2420 (54.4) | 1578 (49.6) | 2134 (51.2) | < 0.001 | 0.003 | 0.185 |
| Dyspareunia | 1536 (13.0) | 562 (12.6) | 413 (13.0) | 561 (13.5) | 0.651 | 0.259 | 0.558 |
| Pelvic pain | 346 (2.9) | 145 (3.3) | 81 (2.6) | 120 (2.9) | 0.070 | 0.305 | 0.389 |
| Abdominal pain | 7935 (67.3) | 2156 (48.5) | 2354 (74.1) | 3425 (82.2) | < 0.001 | < 0.001 | < 0.001 |
| Infertility | 1414 (12.0) | 374 (8.4) | 421 (13.2) | 619 (14.9) | < 0.001 | < 0.001 | 0.050 |
| Count of endometriosis symptoms,a mean (SD) | 1.5 (0.7) | 1.3 (0.5) | 1.5 (0.7) | 1.7 (0.7) | < 0.001 | < 0.001 | < 0.001 |
| Symptom severity proxy (annualized count), mean (SD) | 0.6 (0.5) | 1.0 (0.7) | 0.5 (0.2) | 0.3 (0.1) | < 0.001 | < 0.001 | < 0.001 |
| Most common endometriosis-related comorbidities, n (%) | |||||||
| Fatigue neurasthenia | 5804 (49.2) | 1912 (43.0) | 1617 (50.9) | 2275 (54.6) | < 0.001 | < 0.001 | 0.002 |
| Headache and migraine | 5046 (42.8) | 1566 (35.2) | 1417 (44.6) | 2063 (49.5) | < 0.001 | < 0.001 | < 0.001 |
| Ovarian cysts | 4790 (40.6) | 1604 (36.1) | 1314 (41.3) | 1872 (44.9) | < 0.001 | < 0.001 | 0.002 |
| Urinary tract infection | 4570 (38.8) | 1374 (30.9) | 1350 (42.5) | 1846 (44.3) | < 0.001 | < 0.001 | 0.118 |
| Depression and anxiety | 4437 (37.6) | 1428 (32.1) | 1223 (38.5) | 1786 (42.9) | < 0.001 | < 0.001 | < 0.001 |
| Uterine fibroids | 4034 (34.2) | 1515 (34.1) | 1089 (34.3) | 1430 (34.2) | 0.870 | 0.819 | 0.962 |
| Count of comorbid conditions, n (%) | |||||||
| 0 | 491 (4.2) | 289 (6.5) | 97 (3.1) | 105 (2.5) | < 0.001 | < 0.001 | 0.167 |
| 1 | 1467 (12.4) | 766 (17.2) | 343 (10.8) | 358 (8.6) | < 0.001 | < 0.001 | 0.001 |
| 2+ | 9835 (83.4) | 3391 (76.3) | 2739 (86.2) | 3705 (88.9) | < 0.001 | < 0.001 | < 0.001 |
SD standard deviation
aEndometriosis symptoms included dysmenorrhea, dyspareunia, pelvic pain, abdominal pain, and infertility