Table 1.

Effect of sulodexide on the symptoms and signs of CVD, expressed as standardised mean change from baseline and 95% confidence interval

Symptom/sign	Cases	Standardised mean change from baseline	95% CI	Notes
Total score	483	1.63	1.18; 2.25	Studies contributing to the measurement used different number of symptoms to compute the sum of scores
Pain	910	2.51	1.20; 3.82
Cramps	1427	1.59	1.16; 2.02
Paraesthesia	747	1.13	0.76; 1.50
Heaviness	948	1.95	1.23; 2.68
Oedema	1005	1.54	0.97; 2.10	One study used the measurement of volume instead of the score
Discoloration	418	0.34	0.40; 1.08
Skin temperature	571	1.62	0.82; 2.42