Table 4. Overall diagnostic accuracy of pCLE for the inflammatory findings in the IBS group (n = 37) per patient when considering p-CLE target biopsy as the gold standard (%,95 % CI).
| Cecum 1 | Right colon 1 | Transverse colon 1 | Left colon 1 | Sigmoid 1 | Rectum 1 | Total 2 | |
| Sensitivity | 88 (73–96) | 82 (66–92) | 89 (73–97) | 78 (56–93) | 88 (73–97) | 96 (80–100) | 76 (53–92) |
| Specificity | 94 (80–99) | 91 (77–98) | 95 (83–99) | 88 (76–96) | 90 (76–97) | 78 (63–88) | 91 (79–97) |
| PPV | 95 (82–99) | 91 (77–98) | 94 (80–99) | 75 (53–90) | 88 (73–97) | 69 (51–83) | 76 (53–92) |
| NPV | 86 (71–95) | 82 (66–92) | 90 (77–97) | 90 (78–97) | 90 (76–97) | 97 (87–100) | 91 (79–97) |
| Observed agreement | 90.5 % | 86.4 % | 91.9 % | 85.1 % | 89.1 % | 83.7 % | 86.5 % |
| Inter-rater agreement | 81.1 % (P < 0.001) | 73.1 % (P < 0.001) | 83.7 % (P < 0.001) | 65.7 % (P < 0.001) | 78.2 % (P < 0.001) | 67.0 % (P < 0.001) | 66.8 % (P < 0.001) |
CI, confidence interval; IBS, irritable bowel syndrome; pCLE, probe-confocal laser endomicroscopy.
1
A biopsy was positive for inflammation when Geboes > 0.
2
A case was positive for inflammation when > 3/6 biopsies were Geboes > 0.