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. 2020 Mar 23;16(4):43. doi: 10.1007/s11306-020-01667-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Circos plots of correlations between individual metabolite concentrations. Lines represent Pearson’s correlation coefficients between the individual metabolite concentrations within metabolite groups (outer circle), between metabolite groups (inner circle) and between time points (lines going through the middle of the circle). Red lines represent positive correlations and blue lines represent negative correlations. The brightness of the lines indicates the strength of the correlations, with brighter colors for stronger correlations. a Shows only correlation coefficients lower than − 0.15 and higher than 0.15 and b shows only correlation coefficients lower than − 0.30 and higher than 0.30. AA amino acids, NEFA non-esterified fatty acids, PC.aa diacyl-phosphatidylcholines, PC.ae acyl-alkyl-phosphatidylcholines, Lyso.PC.a acyl-lysophosphatidylcholines, Lyso.PC.e alkyl-lysophosphatidylcholines, SM sphingomyelines, Free Carn free carnitine, Carn.a acyl-carnitines