Table 1.

Particokinetic model inputs.

Parameters	Unit	Cuvette	96-well micro-plate
Liquid media
Height	m	0.033	0.0066
Volume	mL	2	0.2
Temperature	K	310	310
Viscosity	N s m−2	0.00074	0.00074
Density	g mL−1	1	1
Surface area	m2	6.6 × 10−5	3.3 × 10−5
Particle characteristics
Particle diameter $\left(D_p\right)$	nm	17.5	17.5
Primary particle density	g m−3	107	107
Effective particle diameter $\left(D_p^{\mathit{eff}}\right)$	nm	120	120
Protein corona thickness $\left(\frac{D_p^{\mathit{eff}}-D_p}{2}\right)$	nm	51.25	51.25
Effective density	g m−3	1.454×106	1.454×106
Dissolution rate constants
$k_f$	mL m−2 h−1	6	6
$k_p$	mL m−2 h−1	30	30
$k_{p2}$	mL m−2 h−1	103	103
$k_{f2p}$	mL g−2 h−1	1.14 104	1.14 104
$k_{p2f}$	mL g−2 h−1	1.6 104	1.6 104
Grid spacing, Time and Particle dissolution
Grid spacing along particle diameter	m	0.5×10−9	0.5×10−9
Number of high grid spacing		100	100
Time	h	24	24
Particle dissolution to free ions	mL m−2 h−1	0.0006×10−5	0.0006×10−5

Parameters adapted for modelling dissolution in static-cuvette and 96-well micro-plate experiments in bold