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. 2020 Mar 17;10:87. doi: 10.3389/fcimb.2020.00087

Figure 2.

Figure 2

Humoral immune response against DENV3 in mouse sera. Sera were collected at the ninth week after the immunization. (A) Endpoint titers (n = 8) of DENV3-specific NAbs were detected by PRNT50 and recorded as GMT ± SD. The limit of detection (L.O.D.) depicted as a dotted line represents the lowest dilution that the experiment could detect. (B,C) In vitro neutralizing activity and passive protective effect of immunized sera on suckling mice (n = 13 in the pVAX1-D3ME group, n = 10 in the pVAX1 group). The pooled sera mixed with live DENV3 were transferred into 1-day-old suckling mice. The mice were monitored daily for 14 days. (B) Body weight change from day 0. (C) The survival rate is shown as the percentage of survivors. **p < 0.01; ***p < 0.001.