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. 2020 Mar 17;10:87. doi: 10.3389/fcimb.2020.00087

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Copyright © 2020 Feng, Zheng, Wang, Gao, Fan, Sheng, Zhou, Chen and An.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Long-term cross-reactive NAb response and protection against DENV1 (A–D), DENV2 (E–H), and DENV4 (I–L) at the 12th month after the immunization. For DENV1, n = 7 in the pVAX1-D3ME group, n = 5 in the pVAX1 group. For DENV2, n = 6 in the pVAX1-D3ME group, n = 5 in the pVAX1 group. For DENV4, n = 7 in the pVAX1-D3ME group, n = 5 in the pVAX1 group. (A,E,I) Endpoint titers of cross-reactive NAbs in sera were detected by PRNT₅₀ and recorded as GMT ± SD. The L.O.D. depicted as a dotted line represents the limit of detection of the assay. (B–D,F–H,J–L) Mice were challenged with DENVs and monitored daily for 27 days. (B,F,J) Pathological symptoms recorded as the mean clinical sign scores. (C,G,K) Percentage of body weight from day 0. (D,H,L) Survival rate shown as the percentage of survivors. *p < 0.05; **p < 0.01; ***p < 0.001.