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. 2020 Mar 17;11:236. doi: 10.3389/fphar.2020.00236

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Copyright © 2020 Wang, Li, Tu, Chen, Zeng and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TGs significantly decrease the expression of Keap-1 and facilitate the nuclear translocation of Nrf-2. Representative images obtained from the cortex penumbraof ischemic hemispheres. (A) Keap-1 dependent Nrf-2 nuclear translocation was observed in I/R rats brain tissue. (C) Keap1 degradation after TGs treatment to I/R rats braintissue. The analysis was carried out using immunofluorescence staining. af are NOR, MOD, EDI, TGs, PSs and OSs groups, respectively. (B, D) Bar graphs show aquantification of the nucleus/cytoplasmic ratio of Nrf-2 and the expression of Keap-1. *P < 0.05 vs NOR, ^# P < 0.05 vs MOD. Scale bar = 100 mm.