Figure 13.

Summary of findings. DIO selectively supresses de novo FA synthesis and lipolysis in mammary adipose tissue, but increased lipogenesis and lipolysis in tumor tissue. Exogenous dietary lipids can alter the energy metabolism of triple-negative breast cancer tumors in this current in vivo model. Alterations in FAs composition in both mammary adipose and tumor tissue could be a mechanism by which FAs composition can be altered in response to DIO within the tumor microenvironment and thereby contributing to the decreased efficacy of breast cancer treatment agent within our current model.