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. 2020 Mar 17;10:306. doi: 10.3389/fonc.2020.00306

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Copyright © 2020 Mentoor, Nell, Emjedi, van Jaarsveld, de Jager and Engelbrecht.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Mean body weight, and (B) food consumption of mice (n = 5 per cage) receiving vehicle-or doxorubicin treatment while on the LFD control compared to the HFD. Results are presented as mean ± SEM (n = 10 per group). Three-way ANOVA with Fisher's LSD post hoc correction was applied and p < 0.05 was considered as statistically significant. ***p < 0.001 and ****p < 0.0001. ^#p < 0.05, ^##p < 0.01, ^####p < 0.0001, ^$$$p < 0.001 and ^$$$$p < 0.0001. *Vehicle-L vs. Vehicle-H, ^#Dox-L vs. Dox-H, and ^$Vehicle-H vs. Dox-H.