Fig. 1. Plasminogen accelerates and improves the quality of healing in radiation wounds.

a The timescale for radiation wound formation and treatment. b Representative photographs of the dorsal skin of wild-type mice at day 0 (before treatment) and at different time points with plasminogen or PBS treatment. Arrows show the wounds on the skin. c Quantification of the remaining wound area at different time points of treatment in the PBS-treated wounds (n = 6) and plasminogen-treated wounds (n = 6). d Representative photographs of hematoxylin and eosin-stained sections of normal/healthy skin, and sections of radiation wounds at day 0 before treatment, and at days 20 and 30 of PBS or plasminogen treatment. e Epidermal thickness of healthy skin (control, n = 3) and thickness of the epidermis in radiation wounds treated with plasminogen (n ≥ 3) or PBS (n ≥ 3) at days 20 and 30 of treatment. f, g Characterization of the healing quality of wounds treated with PBS or plasminogen at days 20 and 30, respectively, performed according to the scoring system presented in Supplementary Table 1. *P < 0.05, ** P < 0.01; ns not significant (P > 0.05); plg plasminogen. Scale bar = 100 µm.