Fig. 2. Plasminogen treatment reduces the accumulation of fibrin and neutrophils in radiation wounds.

a Immunostaining of fibrin (yellow) and neutrophils (red) performed on paraffin sections from healthy skin (no irradiation), skin at 10 days after irradiation (day 0), and radiation wounds treated with PBS or plasminogen at days 20 and 30. DAPI staining is shown in blue. b, c Quantification of neutrophils and fibrin (respectively) in healthy skin, non-treated radiated skin (day 0), and in PBS- and plasminogen-treated radiation wounds at days 20 and 30 (n ≥ 3). *P < 0.05, **P < 0.01; scale bar = 100 µm.