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. 2020 Mar 23;11(3):201. doi: 10.1038/s41419-020-2397-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Expression of genes that are involved in fibrosis that were significantly changed at day 20 of plasminogen treatment when compared with PBS treatment, as measured using mRNA sequencing. Rich factor is the ratio of the number of target genes divided by the number of all the genes in each pathway. b The KEGG enrichment scatter plot of genes regulating metabolism that were significantly changed at day 20 of plasminogen treatment compared with PBS treatment, as identified by mRNA sequencing. Downregulated genes are shown in green, and pathways that include both upregulated and downregulated genes are shown in orange. c Expression of genes involved in the regulation of glycolysis that were significantly changed in plasminogen-treated wounds at day 20 when compared with PBS-treated wounds, as measured using mRNA sequencing. d A model for the molecular mechanisms by which plasminogen enhances the healing of radiation wounds.