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. 2020 Mar 23;11:1517. doi: 10.1038/s41467-020-15328-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Overnight fasting blood glucose and insulin levels at 22 weeks of age. Male: LepR-Cre: n = 8 (insulin) and n = 9 (glucose), Sh2b1^ΔLepR: n = 8; female: LepR-Cre: n = 5, Sh2b1^ΔLepR: n = 6. b GTT and ITT at 20 weeks of age. Male: LepR-Cre: n = 9, Sh2b1^ΔLepR: n = 8; female: f/f: n = 5, Sh2b1^ΔLepR: n = 5. c Male mice (23 weeks) were stimulated with insulin. Liver and skeletal muscle extracts were immunoblotted with the indicated antibodies. Male: f/f: n = 6, Sh2b1^ΔLepR: n = 6; female: f/f: n = 6, Sh2b1^ΔLepR: n = 6. d Representative H&E staining of liver sections at 23 weeks of age (3 pairs). Scale bar: 200 μm. e Liver TAG levels (normalized to liver weight) at 23 weeks of age. Male: f/f: n = 5, Sh2b1^ΔLepR: n = 4; female: f/f: n = 6, Sh2b1^ΔLepR: n = 6. Data are presented as mean ± SEM. *p < 0.05, two-tailed unpaired Student’s t-test. Source data are provided as a Source Data file.