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. 2020 Mar 24;10:5665. doi: 10.1038/s41598-020-62492-z

Author Correction: Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions

Marie-Laëtitia Thézénas 1,#, Bianca De Leo 2,#, Alexis Laux-Biehlmann 2, Cemsel Bafligil 3, Bernd Elger 2, Thomas Tapmeier 4, Karl Morten 4, Nilufer Rahmioglu 4,5, Stephanie G Dakin 3, Philip Charles 1, Fernando Estrada Martinez 3, Graham Steers 4, Oliver M Fischer 2, Joerg Mueller 2, Holger Hess-Stumpp 2, Andreas Steinmeyer 2, Sanjiv Manek 4, Krina T Zondervan 4,5, Stephen Kennedy 4, Christian M Becker 4, Catherine Shang 3,4, Thomas M Zollner 2, Benedikt M Kessler 1,, Udo Oppermann 3,6,
PMCID: PMC7089969  PMID: 32205848

Correction to: Scientific Reports 10.1038/s41598-020-58362-3, published online 30 January 2020

In Figure 5A, the chemical structure is incorrect. As a result, the Figure legend,

“AOC3 inhibitor PXS-4681A shows analgesic effects in the endometriosis inoculation mouse model.

(A) Structure of AOC3 inhibitor PXS-4681A, orally administered BID at 2 mg/kg. (B) Unbound plasma levels of PXS-4681A (at 1-2-4 mg/kg). (C) Target engagement results (2 mg/kg). (D) Changes in H2O2 in plasma. (E) Plasma exposure of PXS-4681A at day 2. (F) Front/rear paw ratio measure using the dynamic weight bearing system indicating reduction of pain behaviour under treatment.”

should read:

“AOC3 inhibitor PXS-4681A shows analgesic effects in the endometriosis inoculation mouse model.

(A) Structure of AOC3 inhibitor PXS-4681A, orally administered BID at 2 mg/kg. The compound was synthesized according to literature procedures37 (B) Unbound plasma levels of PXS-4681A (at 1-2-4 mg/kg). (C) Target engagement results (2 mg/kg). (D) Changes in H2O2 in plasma. (E) Plasma exposure of PXS-4681A at day 2. (F) Front/rear paw ratio measure using the dynamic weight bearing system indicating reduction of pain behaviour under treatment.”

The correct Figure 5 and its accompanying legend appear below as Figure 1.

Figure 1.

Figure 1

AOC3 inhibitor PXS-4681A shows analgesic effects in the endometriosis inoculation mouse model. (A) Structure of AOC3 inhibitor PXS-4681A, orally administered BID at 2 mg/kg. The compound was synthesized according to literature procedures37 (B) Unbound plasma levels of PXS-4681A (at 1-2-4 mg/kg). (C) Target engagement results (2 mg/kg). (D) Changes in H2O2 in plasma. (E) Plasma exposure of PXS-4681A at day 2. (F) Front/rear paw ratio measure using the dynamic weight bearing system indicating reduction of pain behaviour under treatment.

Contributor Information

Benedikt M. Kessler, Email: benedikt.kessler@ndm.ox.ac.uk

Udo Oppermann, Email: udo.oppermann@ndorms.ox.ac.uk.


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