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. 2020 Mar 23;10:5226. doi: 10.1038/s41598-020-62067-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Interaction analysis results. Decreased activation was found in the prefrontal lobe during the performance of the PASAT task in the trained group after the n-back training. (a) Trained group (pre-training > post-training) > Control group (pre-training > post-training) and (b) Trained group (pre-training > follow-up) > Control group (pre-training > follow-up). A corrected FDR threshold of p-value < 0.05 (cluster correction, criterion: 113 voxels of extension for contrast 1 and 99 voxels of extension for contrast 2) and an uncorrected threshold of p-value < 0.001 (voxel level) were used.