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. 2020 Mar 23;11:1518. doi: 10.1038/s41467-020-15297-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Schematic illustration of size-selective molecular recognition to distinguish mature microRNA from precursor microRNA. b Schematic illustration of different lengths of nucleic acid targets containing the same recognition sequence of miRNA-21. c, d Fluorescence response of free MB (c) and Cage-MB-in (d) to the nucleic acid targets with different lengths (F: fluorescence intensity in the presence of target, F₀: fluorescence intensity in absence of target) ; Data are presented as mean values ± s.d. (n = 4), ns = 0.17 (0.30, 0.37) for T10-miRNA 21- T10 (T20-miRNA 21- T20, T30-miRNA 21- T30) to Free MB > 0.05 (not significant), ***p = 0.00089 (0.00021, 0.000068) for T10-miRNA 21-T10 (T20-miRNA 21-T10, T30-miRNA 21-T30) to Cage-MB-in <0.001, by two-tailed unpaired Student’s t-test. e–f Fluorescence study of the fluorescence response of Cage-MB-out (e) and Cage-MB-in (f) to pre-miRNA-21 and mature miRNA-21. Source data are provided as a Source Data file.