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. 2020 Mar 23;11:1518. doi: 10.1038/s41467-020-15297-7

Fig. 7. Size-selective discrimination between mature microRNA and precursor microRNA in living cells.

Fig. 7

a, b Fluorescence confocal imaging of MCF-7, HeLa and HEK293 cells incubated with 100 nM Cage-MB-in and Cage-MB-out (a) and the normalized mean fluorescence by ImageJ (b); Data are presented as mean values ± s.d. (n = 5), ***p = 0.00000068 (0.000000036), 0.0000014 for HeLa (HEK293) to Cage-MB-in, HEK293 to Cage-MB-out < 0.001, ns = 0.93 > 0.05 (not significant), by two-tailed unpaired Student’s t-test. c Fluorescence confocal imaging of HeLa cells treated with and without 5 μM miRNA-21 inhibitor PLL before incubating with 100 nM Cage-in. The scale bars are 20 μm. Source data are provided as Source Data file.