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. 2020 Mar 23;10:5224. doi: 10.1038/s41598-020-62117-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Netrins mutations in cancer. (a) Netrins exhibit non-synonymous mutations in the coding region in 26 kinds of TCGA cancers. Each gray vertical bar represents a patient. (b) Amino acid mutation of netrins in TCGA cancers. Hot spot mutations are indicated. Substituted mutations are represented by slash-separated single-letter amino acid codes. Other indicates important mutation sites that predicted as damaging in both VEST3 and REVEL algorithms in the VEST3 and REVEL algorithms and coverage < 0.1 in the functional and structural importance of the protein sequence position. Fs, frameshifts; *, termination codon. (c) Amino acid mutation of netrins in Cancer Cell Line Encyclopedia (CCLE). Substituted mutations are represented by slash-separated single-letter amino acid codes. Other represents a mutation site consistent with TCGA mutation in CCLE.