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. 2020 Mar 23;11:1521. doi: 10.1038/s41467-020-15329-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — (a) Graphical abstract of ICV injection for directly infecting the brain parenchyma with C. neoformans. (b–e) ICV-STM score of brain-infection-related (b) kinases, (c) TFs, core-virulence (d) kinases, and (e) TFs. Three mice (A/J) were infected with each pooled mutant group (Supplementary Data 4), sacrificed after 7 dpi, and infected brain tissues were harvested for recovering cryptococcal cells. The ICV-STM score was calculated by quantitative PCR of genomic DNA isolated from input and output cryptococcal mutants as described in Methods. The ste50Δ mutant was used as a virulent control strain. Red and blue marks (with *) indicate mutants whose STM scores are statistically different (P < 0.05, n = 3) from the ste50Δ STM score by one-way ANOVA analysis with Bonferroni’s multiple comparison test. Data are presented as mean values ± SEM.