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. 2020 Mar 23;11:1521. doi: 10.1038/s41467-020-15329-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Gene Ontology (GO) term-based categorisation of lung-infection-related, brain-infection-related, and core-virulence kinases and TFs, which are summarised in Supplementary Data 2 and 3, are illustrated. Asterisk (*) indicates gene deletion mutants that exhibit growth defects at mammalian body temperature. Blue and red letters denote kinases and TFs, respectively, involved in the virulence of C. neoformans. Bold letters indicate kinases and TFs that play important roles in both BBB crossing and survival in brain parenchyma.