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. 2020 Mar 23;11:1522. doi: 10.1038/s41467-020-15309-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Virus-induced type I IFN responses transiently impair the Treg cell compartment. The Treg pool is rapidly replenished by iTreg cells converted from a high-affinity CD4⁺ T cell population (Vβ5⁺ CD4⁺ T cells in mice and Vβ2⁺ CD4⁺ T cells in humans) and returns to homeostasis. If this process is impaired, the lack of Treg-mediated suppression allows for a colitogenic immune response to be triggered, leading to intestinal immune pathology.