Table 2.
Clinical and genetic characteristics of the 15 patients had azathioprine-induced leukopenia
| NUDT15 C/C | NUDT15 C/T | NUDT15 T/T | ANOVA test | |
|---|---|---|---|---|
| Patient numbers | 4 | 8 | 3 | |
| Age ± SD (years) | 64.00 ± 23.45 | 52.63 ± 22.32 | 43.00 ± 21.28 | 0.4839 |
| Sex (male to female) | 1:3 | 4:4 | 3:0 | 0.2037 |
| Underlying disease | 1.000* | |||
| Generalized eczema | 3 | 6 | 2 | |
| Atopic dermatitis | 1 | 1 | 1 | |
| Bullous pemphigoid | 0 | 1 | 0 | |
| Neutrophil count | 701.79 ± 544.77 | 819.81 ± 320.82 | 297.26 ± 397.59 | 0.1978 |
| Interval | 70.75 ± 46.84 | 67.88 ± 35.18 | 26.33 ± 19.66 | 0.2362 |
| Early neutropenia | 2 (50%) | 5 (62.5%) | 3 (100%) | 0.6084* |
*Fisher’s exact test