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. 2020 Mar 17;11:137. doi: 10.3389/fphys.2020.00137

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Copyright © 2020 Azhar, Lim, Tan and Angeli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interplay and chronology between lymphedema pathological changes are not well understood. It is evident in clinical and animal models of lymphedema that inflammation, adipose tissue remodeling, and fibrosis in skin and lymphatic vessels occur as lymphedema progresses. In particular, chronology of adipose tissue remodeling between lymphedema stages remains unexplored. Moreover, it is not known if adipose tissue remodeling (1) and inflammation are two separate or synchronized events, and whether adipose tissue remodeling in lymphedema can promote fibrosis (2) as observed in obesity.