Table 6.
Clinical and Biochemical Characteristics of T1D Patients with Different Genotypes of rs212704 of the NLRC4 Gene
| Clinical Characteristics | Genotype | P value | ||
|---|---|---|---|---|
| TT | TC | CC | ||
| Sample size | 92 | 251 | 167 | – |
| Sex (men/women) | 50/42 | 138/113 | 87/80 | 0.842 |
| Onset age (year) | 23(12–33) | 19(12–33) | 17(10–30) | 0.130 |
| T1D duration (months) | 4.50(0.31–24.00) | 5.00(0.66–24.00) | 5.00(0.50–16.00) | 0.897 |
| BMI (kg/m2) | 18.50(16.52–20.75) | 18.94(16.80–21.00) | 18.42(16.05–20.18) | 0.097 |
| FCP (pmol/L) | 60.70(14.80–152.20) | 91.57(19.62–172.80) | 64.01(14.49–153.64) | 0.134 |
| PCP (pmol/L) | 128.20(25.72–248.86) | 173.00(62.39–301.07) | 99.90(26.90–236.33) | 0.003* |
| HbA1c (%) | 9.90(7.90–13.10) | 10.05(7.50–12.48) | 10.15(8.00–12.90) | 0.352 |
| GADA positive% | 91.30% | 86.80% | 89.20% | 0.474 |
| GADA titer (U/mL) | 430.25(86.02–773.39) | 320.37(84.66–773.07) | 261.77(78.78–776.45) | 0.504 |
| IA-2A positive% | 46.40% | 48.70% | 44.50% | 0.722 |
| IA-2A titer (U/mL) | 260.19(45.69–803.89) | 181.99(44.86–594.28) | 205.00(68.47–697.46) | 0.424 |
| ZnT8A positive% | 34.80% | 28.30% | 32.80% | 0.496 |
| TG (mmol/L) | 0.88(0.63–1.41) | 0.95(0.71–1.39) | 0.96(0.65–1.44) | 0.688 |
| TC (mmol/L) | 4.30(3.56–4.88) | 4.34(3.73–4.93) | 4.13(3.52–4.88) | 0.335 |
| HDL (mmol/L) | 1.31(1.05–1.67) | 1.23(1.01–1.62) | 1.26(1.10–1.62) | 0.502 |
| LDL (mmol/L) | 2.44(1.77–2.98) | 2.38(1.86–3.01) | 2.11(1.67–2.74) | 0.099 |
Note: *P < 0.05 was considered significant.
Abbreviations: BMI, body mass index; FCP, fasting C-peptide; PCP, 2-h postprandial C-peptide; HbA1c, glycated hemoglobin; GADA, glutamic acid decarboxylase antibody; IA-2A, protein tyrosine phosphatase antibody; ZnT8A, zinc transporter 8 antibody.