Table 7.
Clinical and Biochemical Characteristics of T1D Patients with Different Genotypes of rs385076 of the NLRC4 Gene
| Clinical Characteristics | Genotype | P value | ||
|---|---|---|---|---|
| CC | CT | TT | ||
| Sample size | 82 | 253 | 175 | – |
| Sex (men/women) | 49/33 | 125/118 | 91/84 | 0.493 |
| Onset age (year) | 24(13–36) | 19(12–32) | 17(10–29) | 0.031* |
| T1D duration (months) | 1.25(0.26–12.00) | 6.00(0.70–24.00) | 5.00(0.50–17.00) | 0.096 |
| BMI (kg/m2) | 19.07(16.90–21.03) | 18.82(16.60–20.57) | 18.30(16.00–20.50) | 0.216 |
| FCP (pmol/L) | 60.70(16.40–153.85) | 82.30(17.05–165.35) | 75.02(19.22–163.18) | 0.824 |
| PCP (pmol/L) | 133.80(30.96–279.38) | 144.55(41.36–282.04) | 135.00(36.07–246.17) | 0.602 |
| HbA1c (%) | 9.90(7.70–12.85) | 10.05(7.70–12.38) | 10.20(7.88–13.00) | 0.559 |
| GADA positive% | 96.30% | 87.70% | 85.70% | 0.041* |
| GADA titer (U/mL) | 373.20(89.75–867.73) | 334.36(85.54–753.54) | 269.25(80.52–752.44) | 0.316 |
| IA-2A positive% | 49.30% | 46.50% | 46.40% | 0.907 |
| IA-2A titer (U/mL) | 302.40(54.16–803.89) | 181.99(47.72–565.94) | 205.00(51.96–666.56) | 0.598 |
| ZnT8A positive% | 30.50% | 31.60% | 29.90% | 0.943 |
| TG (mmol/L) | 0.93(0.74–1.52) | 0.97(0.68–1.40) | 0.94(0.67–1.37) | 0.704 |
| TC (mmol/L) | 4.40(3.74–5.31) | 4.31(3.73–4.91) | 4.02(3.50–4.72) | 0.078 |
| HDL (mmol/L) | 1.25(1.01–1.80) | 1.31(1.01–1.67) | 1.25(1.11–1.54) | 0.940 |
| LDL (mmol/L) | 2.38(1.69–3.17) | 2.38(1.90–2.91) | 2.14(1.66–2.75) | 0.189 |
Note: *P < 0.05 was considered significant.
Abbreviations: BMI, body mass index; FCP, fasting C-peptide; PCP, 2-h postprandial C-peptide; HbA1c, glycated hemoglobin; GADA, glutamic acid decarboxylase antibody; IA-2A, protein tyrosine phosphatase antibody; ZnT8A, zinc transporter 8 antibody.