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Oxymatrine inhibits RAS/RAF/MEK/ERK signaling pathway in SW962 and A431 cells. SW962 and A431 cells were treated with or without oxymatrine (3 mg/mL) and salirasib (20 µM) for 48 h. (A–D) Protein expression of RAS, RAF, MEK, ERK, p-RAF, p-MEK, p-ERK, C-MYC, and MMP2 as detected by Western blotting. *P<0.05, **P<0.01 compared with 0 mg/mL oxymatrine (control group).
