Table 2.

Test for subgroup differences.

Subgroup	All-grade adverse events			Grade 3 or 4 adverse events
	Q-value	Degree of freedom	p-value	Q-value	Degree of freedom	p-value
Cancer type	10.62	7	0.1560	43.42	6	<0.0001
Treatment combination	0.00	1	0.9799	16.01	1	<0.0001
Monotherapy drug	0.18	3	0.9806	3.03	2	0.2197
Drug regimen	3.49	3	0.3221	20.15	2	<0.0001