Table 1.
Differentially Expressed Metabolites Identified in the Olfactory Bulb Between GF and SPF Mice
| Metabolite | RT | m/z | VIP | FDR | Fold Change * |
|---|---|---|---|---|---|
| Inosine-5ʹ-monophosphate | 26.64 | 315 | 1.62 | 4.76E-03 | 1.82 |
| Adenosine | 23.99 | 236 | 1.29 | 2.48E-02 | 1.77 |
| L-Glycerol-3-phosphate | 15.55 | 357 | 1.45 | 1.08E-02 | 1.73 |
| Adenosine-5-monophosphate | 27.26 | 315 | 1.79 | 1.33E-03 | 1.55 |
| α-Hydroxyglutaric acid | 13.3 | 129 | 1.87 | 2.09E-04 | 0.93 |
| Myo-inositol | 17.72 | 318 | 2.06 | 7.98E-05 | 0.79 |
| Itaconic acid | 10.12 | 215 | 1.22 | 3.04E-02 | 0.71 |
| L-Threonine | 10.72 | 218 | 1.72 | 2.03E-03 | 0.67 |
| Arabinofuranose | 15.62 | 217 | 1.74 | 2.03E-03 | 0.63 |
| D-Glucose | 17.06 | 319 | 1.17 | 3.77E-02 | 0.57 |
| L-Glutamic acid | 13.89 | 246 | 1.26 | 2.74E-02 | 0.57 |
| L-Serine | 10.36 | 204 | 1.6 | 4.79E-03 | 0.53 |
| 3-Hydroxybutyric acid | 7.34 | 117 | 1.84 | 8.09E-04 | 0.53 |
| Glycolic acid | 6.03 | 177 | 1.45 | 1.04E-02 | 0.48 |
| L-Valine | 8.21 | 144 | 1.54 | 7.34E-03 | 0.37 |
| 2-Monopalmitoylglycerol | 23.32 | 129 | 1.14 | 4.22E-02 | 0.34 |
| 2,4-dihydroxybutyric acid | 11.09 | 103 | 1.4 | 1.32E-02 | 0.32 |
| Arabitol | 15.04 | 217 | 1.13 | 4.36E-02 | 0.32 |
| Fumaric acid | 10.25 | 245 | 1.3 | 2.35E-02 | 0.29 |
| Malic acid | 12.16 | 233 | 1.1 | 4.98E-02 | 0.26 |
| Xylitol | 14.88 | 217 | 1.25 | 2.75E-02 | 0.26 |
| Threonic acid-1,4-lactone | 10.6 | 247 | 1.24 | 2.79E-02 | 0.26 |
| Pyroglutamic acid | 12.7 | 156 | 1.47 | 9.59E-03 | 0.17 |
| γ-Aminobutyric acid | 12.8 | 304 | 1.52 | 7.90E-03 | −0.25 |
| L-Ornithine | 16.24 | 142 | 1.3 | 2.31E-02 | −0.26 |
| D-(-)-Erythrose | 11.43 | 205 | 1.19 | 3.33E-02 | −0.29 |
| L-Aspartic acid | 12.63 | 232 | 1.95 | 2.01E-04 | −0.32 |
| Ethanolamine | 8.99 | 174 | 1.6 | 5.02E-03 | −0.43 |
| L-Cysteine | 13.08 | 220 | 1.98 | 2.33E-04 | −0.44 |
| Citric acid | 16.22 | 273 | 1.72 | 1.91E-03 | −0.46 |
| Uridine | 22.42 | 217 | 1.69 | 9.56E-03 | −0.46 |
| Urea | 7.65 | 189 | 1.33 | 2.05E-02 | −0.54 |
| Uracil | 10.06 | 241 | 1.94 | 2.05E-04 | −0.62 |
| Guanosine | 25 | 324 | 1.17 | 3.70E-02 | −0.63 |
| L-Glutamine | 15.77 | 156 | 1.48 | 1.00E-02 | −0.7 |
| L-Cystine | 21.09 | 218 | 1.54 | 7.04E-03 | −0.73 |
| 2,6-dihydroxypurine | 18.41 | 353 | 1.77 | 1.44E-03 | −1.02 |
| Hypoxanthine | 16.18 | 265 | 2.12 | 3.26E-05 | −1.02 |
Notes: *Fold change was calculated as the logarithm of the average mass response (area) ratio between the two groups (ie, fold change = log2[GF/SPF]).