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Four main types of tumor heterogeneity. Interpatient heterogeneity (top-left) describing differences between patients with similar tumor histology. Intertumor heterogeneity (top-right) describes differences between tumor foci in the same patient. Intratumor heterogeneity (bottom-left) demonstrates differences in tumor cells within the one tumor foci and lastly treatment associated heterogeneity (bottom-right) describes temporal changes in a tumor at intervals throughout treatment.
