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. 2020 Mar 18;12:2001–2014. doi: 10.2147/CMAR.S240695

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© 2020 Tang et al.

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Up-regulation of lncRNA-ATB promotes cisplatin resistance in LUAD cells. (A) The half-maximal inhibitory concentration (IC₅₀) of cisplatin in A549/CDDP cells was significantly greater than in A549 cells. (B) LncRNA-ATB was strikingly elevated in A549/CDDP cells compared with parental A549 cells. (C) Successful construction of A549-ATB-OE cells was validated by RT-qPCR. (D) The effects of different concentrations of cisplatin on proliferation of A549-ATB-OE and A549 cells were detected by CCK-8 assay. (E) IC₅₀ of cisplatin in A549-ATB-OE cells was remarkably higher than that in A549 cells. (F) Successful construction of A549-ATB-sh cells was validated by RT-qPCR. (G) The effects of various concentrations of cisplatin on proliferation of A549-ATB-sh and A549 cells were detected by CCK-8 assay. (H) IC₅₀ of cisplatin in A549-ATB-sh cells was significantly lower than that in A549 cells. (I) Successful construction of H1975-ATB-OE and H1975-ATB-sh cells was validated by RT-qPCR. (J) IC₅₀ of cisplatin in H1975-ATB-OE and H1975-ATB-sh cells. Data are expressed as mean ± SD from three independent experiments. *P<0.05; **P<0.01; ***P<0.001.