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. 2020 Mar 18;12:2001–2014. doi: 10.2147/CMAR.S240695

Figure 3.

Figure 3

LncRNA-ATB suppresses activation of apoptosis-related proteins. mRNA and protein expression levels of (A) Bax, (B) Bcl-xl, and (C) Bcl-2 in A549-ATB-OE cells were measured by RT-qPCR and Western blotting. No difference was observed in the activation of (D) caspase-3 and (E) caspase-9 between A549-ATB-OE cells and control cells. (F) Active caspase-3 levels were lower in A549-ATB-OE cells treated with cisplatin than in untreated cells. (G) Protein expression levels of Bax, Bcl-xl and Bcl-2 in A549-ATB-sh cells and control cells. (H) Protein and mRNA expression levels of Bax, Bcl-xl and Bcl-2 in H1975 cells overexpressing or silencing lncRNA-ATB. (I) Ratio of cleaved caspase-3/caspase-3 in H1975 cells overexpressing or silencing lncRNA-ATB following treatment with cisplatin (2 μg/mL). Data are expressed as mean ± SD (n=3). *P<0.05; **P<0.01.