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. 2020 Mar 18;12:2001–2014. doi: 10.2147/CMAR.S240695

Figure 5.

Figure 5

LncRNA-ATB regulates the miR-200a/β-catenin pathway. (A) miR-200a was significantly down-regulated in A549/CDDP cells compared to A549 cells. (B) β-Catenin expression was greatly up-regulated in A549/CDDP cells compared with A549 cells at both transcriptional and translational levels. (C) miR-200a was strikingly reduced in A549-ATB-OE cells in comparison with control cells. (D) β-Catenin was highly expressed in A549-ATB-OE cells compared with control cells. (E) Vimentin and cyclin D1 expression was decreased in A549-ATB-OE cells compared with control cells. (F) miR-200a was greatly increased in A549-ATB-sh cells compared with control cells. (G) mRNA and protein expression levels of β-catenin, vimentin and cyclin D1 in A549-ATB-sh cells and A549 cells were quantified by RT-qPCR and Western blotting assays. Data are expressed as mean ± SD (n=3). *P<0.05.