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. 2020 Mar 18;12:2001–2014. doi: 10.2147/CMAR.S240695

Figure 6.

Figure 6

Effects of miR-200a overexpression on expression of β-catenin, vimentin and cyclin D1. mRNA and protein expression levels of (A) β-catenin, (B) cyclin D1 and (C) vimentin in A549-ATB-OE cells were significantly higher than in control cells, while further treatment with miR-200a mimics (24 h) could partially reverse their expression. Expression of (D) β-catenin, (E) cyclin D1 and (F) vimentin was significantly lower in A549-ATB-sh cells than in control cells, whereas treatment with an miR-200a antagomir could partially reverse their expression. (G) mRNA expression levels of β-catenin, cyclin D1 and vimentin in H1975-ATB-OE cells treated with or without miR-200a mimics. (H) mRNA expression levels of β-catenin, cyclin D1 and vimentin in H1975-ATB-sh cells with or without miR-200a antagomir treatment. (I) mRNA expression levels of β-catenin, cyclin D1 and vimentin in H1975-ATB-OE cells with or without IWR-1 (500 nM) treatment for 48 h. Data are expressed as mean ± SD (n=3). *P<0.05; **P<0.01; NS, not significant.