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. 2020 Mar 18;13:2333–2345. doi: 10.2147/OTT.S232953

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© 2020 Jiang et al.

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Effect of miR-221-5p on cell proliferation, invasion, migration and apoptosis. (A) miR-221-5p low expression in gastric cancer cells; (B) expression of miR-221-5p after transfection; (C and D) effects of up-regulating miR-221-5p and down-regulating miR-221-5p expression on proliferation of gastric cancer cells; (E) effect of up-regulating miR-221-5p and down-regulating miR-221-5p expression on invasion of gastric cancer cells; (F) effect of up-regulating miR-221-5p and down-regulating miR-221-5p expression on gastric cancer cell migration; (G) effect of up-regulating miR-221-5p and down-regulating miR-221-5p expression on apoptosis of gastric cancer cells; (H) Flow cytometry of apoptosis; (I) effects of up-regulating miR-221-5p and down-regulating miR-221-5p expression on EMT-related proteins N-cadherin, vimentin and E-Cadherin in gastric cancer cells; (J) protein image; (K) effect of up-regulating miR-221-5p and down-regulating miR-221-5p expression on apoptosis-related proteins Bax, Bcl-2 and Caspase-3 in gastric cancer cells; (L) protein image. ** indicates that P<0.05.