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. 2020 Mar 17;11:239. doi: 10.3389/fphar.2020.00239

Figure 2.

Figure 2

Metabolic pathways affecting ferroptosis. The brown box contains three currently known pathways: Lipid Oxidation Metabolism、Glutathione Metabolic Pathway、Iron Metabolic Pathway and some related mechanisms of action. Several pharmacological inducer have been shown to induce ferroptosis (eg erastin、RSL3). A variety of ferroptosis inhibitors inhibit iron death from various pathways (eg Fer-1、lip-1、BP、DFO). AA, Arachidonic acid; ACSL4, Acyl-CoA synthetase long-chain family member 4; AKR1C1-3, Aldo-keto reductase family 1 member C1-3; Atg5, autophagy-related 5; Atg7, autophagy-related 7; CISD1, CDGSH iron domain 1; Cys, cysteine; Cys2, cystine; DFO, Deferoxamine; DMT1, Divalent metal transporter 1; Fer-1, Ferrostatin-1; Glu, Glutamate; Gly, glycine; GPX4, Glutathione peroxidase 4; G6PD, Glucose-6-phosphate dehydrogenase; GSH, Glutathione; GSSH, Glutathione disulfide; IREB2, Iron-responsive element-binding protein 2; Lip-1, Liproxstatin-1; LOX, Lipoxygenase; LPCAT3, Lysophosphatidylcholine acyltransferase 3; NADPH, Nicotinamide adenine dinucleotide phosphate; NRF2, Nuclear factor erythroid 2-related factor 2; PE, Phosphatidylethanolamine; PGD, 6-Phosphogluconate dehydrogenase; PKC, Protein kinase C; RSL3, Ras-selective lethal small molecules 3; SLC7A11, Solute carrier family 7 member 11.