Table 2.
Initiators of Ferroptosis.
| Compound | Target | Chemical structures | Model |
|---|---|---|---|
| Erastin (Dolma et al., 2003; Yagoda et al., 2007) |
System xc- and VDAC2/3 |
|
HT-1080 cell BJeLR cell Calu-1 cell |
| PE (Yang et al., 2014) |
System xc- and VDAC2/3 |
|
HT-1080 cell BJeLR cell DRD cell |
| IKE (Larraufie et al., 2015) |
System xc- |
|
CCF-STTG1 cell HT-1080 cell BJeH cell BJeHLT cell DRD cell |
| Sorafenib (Louandre et al., 2013; Louandre et al., 2015) | System xc- mitochondria ROS |
|
HCC cell |
| Sulfasalazine (Gout et al., 2001) |
System xc- |
|
Nb2-SFJCD1 cell Nb2-U17 rats |
| Lanperisone (Shaw et al., 2011) |
System xc- |
|
MEFs cell Mox2-Cre mice |
| RSL3 (Yang et al., 2014) |
GPX4 |
|
HT-1080 cell BJeLR cell BJeHLT cell 4 BJ cell |
| RSL5 (Yang and Stockwell, 2008) |
VDAC2/3 |
|
BJeH cell BJeHLT cell BJeLR cell |
| BSO (Yang et al., 2014) |
GSH depletion |
|
BJeLR cell BJeH cell BJeHLT cell DRD cell |
| DPI2 (Yang et al., 2014) (class I FINs) |
GSH depletion |
|
BJeLR cell |
| DPI7 (Yang et al., 2014) (class II FINs) |
GPX4 |
|
BJeLR cell |
| Acetaminophen (Lorincz et al., 2015) | GSH depletion |
|
HepG2 cell NMRI mice |
| Artesunate (Eling et al., 2015) |
GSH depletion |
|
Panc1 cell COLO357 cell AsPC-1 cell BxPC-3 cell 293T cell HPDE cell PDAC cell |
| FIN56 (Shimada et al., 2016b) |
Promote the degradation of GPX4 Reduce the abundance of CoQ10 |
|
BJeLR cell DRD cell BJeHLT cell BJeH cell HT-1080 cell 143B cell Calu-1 cell |
| FINO2 (Gaschler et al., 2018a) |
Oxidize ferrous iron Inactivate GPX4 indirectly |
|
HT-1080 cell BJ-5ta cell BJeLR cell CAKI-1 cell |
| Silica-based nanoparticles (Kim et al., 2016) |
GSH depletion and increase iron | M21 cell HT-1080 cell 786-O cell |
|
| Cisplatin (Yamaguchi et al., 2013) | GSH depletion |
|
H1299 cell A549 cell PC9 cell |