Table 3.
Inhibitors of Ferroptosis.
| Compound | Target | Chemical structures | Model |
|---|---|---|---|
| Ferrostatin-1 (Skouta et al., 2014) |
ROS from lipid peroxidation |
|
HT-1080 cell |
| SRS 11-92 (Skouta et al., 2014) |
ROS from lipid peroxidation |
|
HT-1080 cell |
| SRS 16-86 (Linkermann et al., 2014) |
ROS from lipid peroxidation |
|
C57BL/6 mice FADD fl/fl mice RIPK3- deficient mice |
| Liproxstatin-1 (Friedmann Angeli et al., 2014) | ROS from lipid peroxidation |
|
HRPTEpiCs cell HK-2 cell |
| α-tocopherol (Burton and Ingold, 2002) |
Oxidative pathway |
|
Pfa1 cell |
| 2,6-di-tert-buyl-4-methylphenol (BHT) (Lucarini et al., 1996) |
Oxidative pathway |
|
HT-1080 cell |
| β-carotene (Yagoda et al., 2007) |
Oxidative pathway |
|
HT-1080 cell BJeLR cell Calu-1 cell |
| N-acetylcysteine (Dixon et al., 2012) (NAC) |
Oxidative pathway |
|
BJeH cell BJeHLT cell BJeLR cell HT-1080 cell DRD cell, MEFs cell |
| Ammonium chloride (Torii et al., 2016) |
Regulation of iron equilibria and ROS generation |
|
HT-1080 cell Calu-1 cell |
| Baf A1 (Torii et al., 2016) |
Regulation of iron equilibria and ROS generation |
|
HT-1080 cell Calu-1 cell |
| PepA-Me (Torii et al., 2016) |
Regulation of iron equilibria and ROS generation |
HT-1080 cell Calu-1 cell |
|
| Deferoxamine (DFO) (Dixon et al., 2012) |
Intracellular iron |
|
BJeH cell BJeHLT cell BJeLR cell HT-1080 cell DRD cell, MEFs cell |
| Deferoxamine mesylate (Yang and Stockwell, 2008) |
Intracellular iron |
|
BJeHLT cell HT1080 cell MIA PaCa-2 cell BJeH cell, A549 cell BJeLR cell, Calu-1 cell |
| 2,2'-bipyridyl (Dixon et al., 2012) |
Intracellular iron |
|
BJeH cell BJeHLT cell BJeLR cell HT-1080 cell DRD cell, MEFs cell |
| Ciclopirox olamine (Dixon et al., 2012) |
Intracellular iron |
|
BJeH cell BJeHLT cell BJeLR cell HT-1080 cell DRD cell, MEFs cell |
| Zileuton (Yang et al., 2016) |
Lipoxygenases |
|
BJeH cell BJeHLT cell BJeLR cell HT-1080 cell |
| NDGA (Probst et al., 2017) |
Lipoxygenases |
|
acute lymphoblastic leukemia cells |
| PD146176 (Yang et al., 2016) |
Lipoxygenases |
|
BJeH cell BJeHLT cell BJeLR cell HT-1080 cell |
| CDC (Yang et al., 2016) |
Lipoxygenases |
|
BJeH cell BJeHLT cell BJeLR cell HT-1080 cell |
| AA-861 (Yang et al., 2016) |
Lipoxygenases |
|
BJeH cell BJeHLT cell BJeLR cell HT-1080 cell |
| BW A4C (Angeli et al., 2017) |
Lipoxygenases |
|
MEFs cell |
| Baicalein (Yang et al., 2016) |
Lipoxygenases |
|
PANC1 cell BxPc3 cell |
| XJB-5-131 (Krainz et al., 2016) |
Nitroxide antioxidant (Oxidative pathway) |
|
HT-1080 cell BJeLR cell panc-1 cell |
| Cycloheximide (Dixon et al., 2012) |
Protein synthesis |
|
BJeH cell BJeHLT cell BJeLR cell HT-1080 cell DRD cell, MEFs cell |
| Diarylamine (Shah et al., 2017) |
Radical-trapping antioxidant |
|
HepG2 cell Pfa1 cell |
| Phenoxazine (Shah et al., 2017) |
Radical-trapping antioxidant |
|
HepG2 cell Pfa1 cell |
| Phenothiazine (Shah et al., 2017) |
Radical-trapping antioxidant |
|
HepG2 cell Pfa1 cell |
| Tetrahydronapthyridinols (Angeli et al., 2017) (THNs) |
Radical-trapping antioxidant |
|
HEK293 cell MEFs cell |
| PMC (Shah et al., 2018) |
Radical-trapping antioxidant |
|
MEFs cell |
| TEMPO (Griesser et al., 2018) |
Radical–trapping antioxidant |
|
MEFs cell |
| Rosiglitazone (Angeli et al., 2017) |
ACSL4 |
|
Caco-2 cell C57BL/6 mice |
| Pioglitazone (Angeli et al., 2017) |
ACSL4 |
|
HepG2 cell Hep3B cell |
| Troglitazone (Angeli et al., 2017) |
ACSL4 |
|
Human breast cancer cell lines SK-BR-3 cell |