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. 2020 Mar 17;14:202. doi: 10.3389/fnins.2020.00202

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Copyright © 2020 Ahamad, Wang, Ge and Kirschen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing of FHL2 increases adult-born DGC dendritic length during early development. (A) Experimental timeline of inducible FHL2 down-regulation with doxycycline induction (dox) at 3 dpi and sacrifice (sac) at 7 dpi. (B) Representative images of GFP control (GFP con) and shFHL2-expressing DGCs at 7 dpi induced at 3 dpi. Scale bar, 10 μm. (C) Quantification of the number of dendritic branches in GFP con and shFHL2-expressing DGCs at 7 dpi. Two-tailed unpaired t-test, p > 0.05. (D) Quantification of total dendrite length for GFP-only expressing control and shFHL2 cells at 7 dpi. Two-tailed unpaired t-test, at 7 dpi, p < 0.05. (E) Sholl analysis at 7 dpi. Two-way ANOVA F (1, 56) = 925.96, p < 0.001. (F) Representative dendritic tracing of control cells and shFHL2 expressing cells dox induced d3 at 7 dpi, scale bar, 20 μm.