Table 1. Baseline Characteristics of Adrenal Cortical Carcinoma Patients (n=46) in the TCPA Database.
| Characteristic | No metastasis (n = 38) | Metastasis (n = 8) | Total (n = 46) | P valuea |
|---|---|---|---|---|
| Age, yr | 47.6±14.8 | 48.0±13.1 | 47.7±14.4 | 0.948 |
| Male sex | 18 (47.4) | 0 | 18 (39.1) | 0.015 |
| Race | 0.440 | |||
| White | 27 (71.1) | 8 (100) | 35 (76.1) | |
| Black | 1 (2.6) | 0 | 1 (2.2) | |
| Asian | 1 (2.6) | 0 | 1 (2.2) | |
| Unknown | 9 (23.7) | 0 | 9 (19.6) | |
| Survival (alive) | 30 (78.9) | 2 (25.0) | 32 (69.6) | 0.006 |
| Follow-up, yr | 3.3 (1.3–5.3) | 2.2 (1.2–3.7) | 3.1 (1.3–5.3) | 0.041 |
| Staging (ENSAT) | <0.001 | |||
| I | 2 (5.3) | 0 | 2 (4.3) | |
| II | 26 (68.4) | 0 | 26 (56.5) | |
| III | 10 (26.3) | 0 | 10 (21.7) | |
| IV | 0 | 8 (100) | 8 (17.4) | |
| Complete resection | 32 (84.2) | 1 (12.5) | 33 (71.7) | <0.001 |
| Chemotherapy | 25 (65.8) | 7 (87.5) | 32 (69.6) | 0.403 |
| Recurrence after complete resectionb | 11 (34.4) | 0 | 11 (33.3) | 1.000 |
| Weiss scorec | 5.8±1.7 | 6.1±3.0 | 5.9±2.0 | 0.503f |
| Mitotic countd | ||||
| Count/HPF | 9.8±8.2 | 33.0±39.9 | 13.6±18.8 | 0.589f |
| No. of >20/HPF | 2 (7.7) | 2 (28.6) | 4 (12.1) | 0.190 |
| Cortisol secretione | 15 (42.9) | 5 (62.5) | 20 (46.5) | 0.440 |
| Differentially expressed proteins | ||||
| High cyclin B1 | 16 (42.1) | 7 (87.5) | 23 (50.0) | 0.047 |
| High TfR1 | 17 (44.7) | 6 (75.0) | 23 (50.0) | 0.243 |
| High fibronectin | 15 (39.5) | 8 (100) | 23 (50.0) | 0.004 |
| High cyclin B1+TfR1 | 11 (28.9) | 6 (75.0) | 17 (37.0) | 0.038 |
| High cyclin B1+fibronectin | 7 (18.4) | 7 (87.5) | 14 (30.4) | <0.001 |
| High TfR1+fibronectin | 8 (21.1) | 6 (75.0) | 14 (30.4) | 0.006 |
| High cyclin B1+TfR1+fibronectin | 7 (18.4) | 6 (75.0) | 13 (28.3) | 0.004 |
Values are expressed as mean±standard deviation, number (%), or median (interquartile range).
TCPA, The Cancer Proteome Atlas; ENSAT, European Network for the Study of Adrenal Tumors; HPF, high power field; TfR1, transferrin receptor.
aP value for a comparison between patients with metastasis and without metastasis; bThe denominator was patients with complete resection; cThe available number was 32 because of missing values; dThe available number was 33 because of missing values; eThe available number was 43 because of missing values; fThe Mann-Whitney test was used, because the Weiss score and mitotic count did not follow normal distributions.