Table 4. Prevalence Ratiosa (95% CI) of NAFLD and Degree of Fibrosis Based on APRI by VSR Quartiles.
| VSR quartile | Number | Case | Age/sex-adjusted PRa (95% CI) | Multivariate-adjusted PRa | |
|---|---|---|---|---|---|
| Model 1 | Model 2 | ||||
| NAFLD+low APRI | |||||
| Q1 (<0.37) | 1,953 | 279 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Q2 (0.37–0.51) | 1,832 | 526 | 1.46 (1.23–1.74) | 1.45 (1.21–1.73) | 2.14 (1.72–2.65) |
| Q3 (0.52–0.70) | 1,848 | 789 | 2.03 (1.70–2.42) | 1.96 (1.64–2.35) | 3.67 (2.94–4.58) |
| Q4 (≥0.71) | 1,832 | 903 | 2.22 (1.85–2.68) | 2.10 (1.73–2.55) | 4.99 (3.93–6.33) |
| P for trend | <0.001 | <0.001 | <0.001 | ||
| NAFLD+intermediate/high APRI | |||||
| Q1 (<0.37) | 1,953 | 16 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Q2 (0.37–0.51) | 1,832 | 49 | 2.46 (1.37–4.42) | 2.56 (1.42–4.63) | 5.04 (2.65–9.59) |
| Q3 (0.52–0.70) | 1,848 | 55 | 2.67 (1.47–4.84) | 2.70 (1.48–4.93) | 7.51 (3.91–14.42) |
| Q4 (≥0.71) | 1,832 | 89 | 4.53 (2.50–8.21) | 4.71 (2.56–8.66) | 19.55 (9.97–38.34) |
| P for trend | <0.001 | <0.001 | <0.001 | ||
CI, confidence interval; NAFLD, nonalcoholic fatty liver disease; APRI, aspartate aminotransferase-to-platelet ratio index; VSR, visceral-to-subcutaneous fat ratio; PR, prevalence ratio.
aEstimated from multinomial logistic regression models as outcomes categorized as no NAFLD, NAFLD plus low APRI, and NAFLD plus intermediate/high APRI. Multivariable model 1 was adjusted for age, sex, center, year of screening examination, smoking status, physical activity, alcohol intake, total energy intake, education level, history of cardiovascular disease, history of diabetes, and history of hypertension; model 2: model 1 plus adjustment for body mass index and homeostasis model assessment of insulin resistance.