Table 1.
Univariate and multivariate analysis of factors influencing the DMFS in breast cancer patients with ILR.
| Factors | DMFS (%) |
p value | Multivariate analysisa |
p value | |||
|---|---|---|---|---|---|---|---|
| 3-yr | 5-yr | HR | 95% CI of HR | ||||
| Age at initial | ≦40 (n = 13) | 84.6 | 67.7 | 0.406 | – | ||
| Diagnosis (years) | >40 (n = 38) | 65.0 | 48.0 | ||||
| Time interval from initial diagnosis to ILR (months) | ≦29 (n = 17) | 47.1 | 29.4 | 0.004 | – | ||
| >29 (n = 34) | 81.9 | 65.1 | |||||
| Size of primary tumor (cm) | ≦2 (n = 29) | 86.2 | 74.5 | <0.001 | – | ||
| >2 (n = 22) | 47.8 | 23.9 | |||||
| Risk groupsb | Group A (≦29, ≦2) (n = 5) | 60.0 | 60.0 | 0.001 | 1.77 | 0.36–8.81 | 0.484 |
| Group B (>29, ≦2) (n = 24) | 91.7 | 77.5 | 1 | ||||
| Group C (≦29, >2) (n = 12) | 41.7 | 16.7 | 8.53 | 2.87–25.34 | <0.001 | ||
| Group D (>29, >2) (n = 10) | 55.6 | 33.3 | 2.30 | 0.73–7.25 | 0.156 | ||
| Initial surgery type | Mastectomy (n = 23) | 60.9 | 43.5 | 0.144 | – | ||
| BCS (n = 28) | 78.0 | 61.8 | |||||
| NBR grade of primary tumor | 1 (n = 17) | 87.8 | 81.6 | 0.007 | 1 | ||
| 2/3 (n = 34) | 61.8 | 42.6 | 6.10 | 1.67–22.23 | 0.006 | ||
| ER status of primary tumor | Negative (n = 3) | 66.7 | 33.3 | 0.709 | – | ||
| Positive (n = 48) | 70.3 | 54.5 | |||||
| PR status of primary tumor | Negative (n = 15) | 50.9 | 36.4 | 0.129 | – | ||
| Positive (n = 36) | 77.8 | 59.8 | |||||
| Her-2 status of primary tumor | Negative (n = 37) | 69.6 | 57.8 | 0.598 | – | ||
| Positive (n = 14) | 71.4 | 40.0 | |||||
| LN status of primary tumor | Negative (n = 22) | 81.1 | 56.1 | 0.381 | – | ||
| Positive (29) | 62.1 | 50.4 | |||||
| Recurrent tumor size (cm) | ≦1 (n = 25) | 72.0 | 63.6 | 0.216 | – | ||
| >1 (n = 26) | 68.2 | 43.8 | |||||
| Chemotherapy after ILR | No (n = 28) | 55.8 | 43.3 | 0.130 | – | ||
| Yes (n = 23) | 87.0 | 63.9 | |||||
| Hormone therapy after ILR | No (n = 21) | 76.2 | 53.2 | 0.645 | – | ||
| Yes (n = 30) | 65.7 | 51.9 | |||||
| Radiotherapy after ILR | No (n = 32) | 77.6 | 60.8 | 0.083 | – | ||
| Yes (n = 19) | 57.9 | 40.5 | |||||
Abbreviations: DMFS: distant-metastatic free survival; ILR: isolated local recurrence; BCS: breast-conserving surgery; NBR: Nottingham Bloom Richardson; ER: estrogen receptor; PR: progesterone receptor; Her-2: human epidermal growth factor receptor 2; LN: lymph node; CI: confidence interval.
a
Multivariate analysis using Cox proportional hazard model.
b
Risk group classification according to time to ILR (≦29 vs. >29 months) and primary tumor size (≦2 vs. >2 cm).