Table 2.
Univariate and multivariate analysis of factors influencing the OS in breast cancer patients with ILR.
| Factors | OS (%) |
p value | Multivariate analysisa |
p value | |||
|---|---|---|---|---|---|---|---|
| 3-yr | 5-yr | HR | 95% CI of HR | ||||
| Age at initial Diagnosis (years) |
≦40 (n = 13) | 92.3 | 83.9 | 0.240 | – | ||
| >40 (n = 38) | 76.3 | 62.5 | |||||
| Time interval from initial diagnosis to ILR (months) | ≦29 (n = 17) | 64.7 | 40.3 | 0.001 | – | ||
| >29 (n = 34) | 88.2 | 81.5 | |||||
| Size of primary tumor (cm) | ≦2 (n = 29) | 93.1 | 85.7 | <0.001 | – | ||
| >2 (n = 22) | 63.6 | 50.0 | |||||
| Risk groupsb | Group A (≦29, ≦2) (n = 5) | 80.0 | 60.0 | <0.001 | 3.05 | 0.51–18.39 | 0.224 |
| Group B (>29, ≦2) (n = 24) | 95.8 | 85.9 | 1 | ||||
| Group C (≦29, >2) (n = 12) | 58.3 | 33.3 | 11.18 | 3.04–41.12 | <0.001 | ||
| Group D (>29, >2) (n = 10) | 70.0 | 70.0 | 3.39 | 0.80–14.42 | 0.098 | ||
| Initial surgery type | Mastectomy (n = 23) | 73.9 | 60.3 | 0.265 | – | ||
| BCS (n = 28) | 85.7 | 73.3 | |||||
| NBR grade of primary tumor | 1 (n = 17) | 94.1 | 81.9 | 0.019 | 1 | ||
| 2/3 (n = 34) | 73.5 | 60.0 | 4.27 | 1.20–15.29 | 0.026 | ||
| ER status of primary tumor | Negative (n = 3) | 66.7 | 66.7 | 0.817 | – | ||
| Positive (n = 48) | 81.2 | 67.4 | |||||
| PR status of primary tumor | Negative (n = 15) | 73.3 | 52.5 | 0.145 | – | ||
| Positive (n = 36) | 83.3 | 74.0 | |||||
| Her-2 status of primary tumor | Negative (n = 37) | 78.4 | 69.5 | 0.812 | – | ||
| Positive (n = 14) | 85.7 | 61.2 | |||||
| LN status of primary tumor | Negative (n = 22) | 90.9 | 76.4 | 0.137 | – | ||
| Positive (29) | 72.4 | 60.7 | |||||
| Recurrent tumor size (cm) | ≦1 (n = 25) | 80.0 | 71.1 | 0.548 | – | ||
| >1 (n = 26) | 80.8 | 65.0 | |||||
| Chemotherapy after ILR | No (n = 28) | 75.0 | 60.0 | 0.073 | – | ||
| Yes (n = 23) | 87.0 | 76.7 | |||||
| Hormone therapy after ILR | No (n = 21) | 85.7 | 68.2 | 0.706 | – | ||
| Yes (n = 30) | 76.7 | 66.5 | |||||
| Radiotherapy after ILR | No (n = 32) | 87.5 | 73.3 | 0.108 | – | ||
| Yes (n = 19) | 68.4 | 57.0 | |||||
Abbreviations: OS: overall survival; ILR: isolated local recurrence; BCS: breast-conserving surgery; NBR: Nottingham Bloom Richardson; ER: estrogen receptor; PR: progesterone receptor; Her-2: human epidermal growth factor receptor 2; LN: lymph node; CI: confidence interval.
a
Multivariate analysis using Cox proportional hazard model.
b
Risk group classification according to time to ILR (≦29 vs. >29 months) and primary tumor size (≦2 vs. >2 cm).