Fig. 3.

Information deduced from the matched images: (a) Region of the mineralization profile (shown in (b)) indicated by the dotted line. (b) Line profile demonstrating the increase in mineral content with increasing distance from the mineralization front (arrows show the site of the labels). (c) traced areas for Ca_DL2 (younger set of double labels, shown in yellow), Ca_DL1 (older set of double labels, shown in turquois), and traced area for Ca_int (indicative for older, highly mineralized interstitial bone, indicated in pink). (d) Analysis of mineralization kinetics: Mean Ca_DL2, Ca_DL1, and Ca_int for each sample. Circles indicate ALN-Rx arm, triangles Rx-Naïve arm, black indicates ALN-Rx Control or Rx-Naïve Control, white indicates cyclic TPTD or daily TPTD. ^⁎⁎⁎p<0.001 versus Ca_DL2, ^###p<0.001 versus Ca_DL1.