Fig 4.

NP patients have increased alpha power and decreased gamma power in the ascending nociceptive pathway. Average resting state MEG activity in the bilateral primary somatosensory cortex (S1), secondary somatosensory cortex (S2), and posterior insula (pINS) of the ascending nociceptive pathway is shown for the mixed inflammatory and neuropathic pain (NP) subgroup (pink), inflammatory none-neuropathic pain (NNP) subgroup (green) and healthy control (HC) subgroups (blue). Increased power in the alpha (8–13 Hz) band and decreased power in the low gamma (31–60 Hz) band in the NP compared to HC group is shown. Lines indicate mean ± SE. Significant group differences (indicated by *) was set using false discovery rate (FDR, p < 0.05) corrected for the number of regions. Regions that survived correction for the multiple frequencies are marked in a red frame. Brain images are displayed using the radiological convention. d – the maximal effect size of significant differences within the region. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article).