Fig. 1.

MHV-A59 infection causes meningitis, choroid plexitis, and ependymitis in the brain of C57BL/6 mice (a–f). Representative images of the cortical meningeal lining (a, b) and choroid plexus in the fourth ventricle (c, d) and lateral-ventricular region (e, f) from mock (a, c, e) and MHV-A59-infected (b, d, f) mice at day 5 p.i. stained with hematoxylin and eosin. Control mice show no sign of inflammation. Inflammation was noted in the cortical meningeal covering (b), choroid plexus (d), and ependyma (f) in infected mouse brains compared to control. Original images have been taken at magnifications of × 40 (a–d) and × 10 (e, f). Arrows in b, d, and f indicate inflamed leptomeninges, choroid plexus, and ependyma in MHV-A59-infected brain sections