Table 2.

Docking scores and interaction profile of two final hit molecules with the inactive (1R0P) and active (2RFS) conformation of c-Met by Autodock

		Docking energy (kcal/mol)
	ZINC ID	Autodock Vina	Autodock 4.2	Estimated IC50 (nM)	H-Bonds	Hydrophobic interactions
1R0P	ZINC08234189	−11.7	−12.91	0.345	P1158 M1160	I1084, R1086, F1089, V1092, A1108, L1140, L1157, Y1159, M1211, D1228, M1229, Y1230, D1231, K1232
2RFS	ZINC03871891	−10.4	−10.54	18.76	R1208 N1209	V1092, L1140, L1157, M1160, D1164, M1211, A1221, D1222, Y1230