Table 3.
Chemokines processed by CD26/DPP4
| TH subset | Chemokine receptor expressed: | Common ligands of these receptors | Substrates of DPP4 activity | Effect of clipping on chemokine activity or receptor preference | N-terminal cleavage | Mr (Da) expasy | Half-life (min) | KCAT/KM (10−6M−1S−1) | References |
|---|---|---|---|---|---|---|---|---|---|
|
Treg (FoxP3, CD26−/low) |
CCR4 | CCL17/TARC (n.d.) | No | ||||||
| CCL22/MDC | Yes | ↓, RP | Gly-Pro▼Tyr | 8090.47 | 1.6 | 4 ± 1 | [10, 41, 82, 166, 167, 185] | ||
| CCR6 | CCL20/MIP-3α (n.d.) | No | |||||||
|
TH2 (GATA3, CRTH2, CD30, CD26+) |
CCR3 | CCL5/RANTES | Yes | RP | Ser-Pro▼Tyr | 7851.01 | 400 | 0.04 ± 0.01 | [10, 41, 82, 167, 185] |
| CCL11/eotaxin 1 | Yes | ↓ | Gly-Pro▼Ala | 8364.90 | 30 | 0.08 ± 0.01 | [10, 41, 82, 166, 167, 185] | ||
| CCL24/eotaxin 2 (n.d.) | No | ||||||||
| CCL26/eotaxin 3 (n.d.) | No | ||||||||
| CCL8/MCP2 (n.d.) | No | ||||||||
| CCL7/MCP3 (n.d.) | No | ||||||||
| CCL13/MCP4 | No | ||||||||
| CCL14a [9–74] | Yes | ↓ | Gly-Pro▼Tyr | 7800.83 | n.d. | n.d. | [188] | ||
| CCL15/MIP-5 | No | ||||||||
| CCL28/MEC | No | ||||||||
| CCR4 | CCL17/TARC | No | |||||||
| CCL22/MDC | Yes | ↓, RP | Gly-Pro▼Tyr | 8090.47 | 1.6 | 4 ± 1 | [10, 41, 82, 166, 167, 185] | ||
| CCR8 | CCL1 | No | |||||||
| CCL17/TARC | No | ||||||||
| CXCR4 | CXCL12/SDF-1α | Yes | ↓, CXCR4 antagonist | Lys-Pro▼Val | 7609.97 | <1 | 5 ± 2 | [10, 41, 82, 166, 167, 185] | |
|
TH1 (t-bet, CD26++) |
CCR5 | CCL3L1/LD78β | Yes | ↑, RP | Ala-Pro▼Lys | 7797.74 | 6000 | 0.003 ± 0.002 | [82, 166, 167, 185] |
| CCL4/MIP-1β | No | ||||||||
| CCL5/RANTES | Yes | RP | Ser-Pro▼Tyr | 7851.01 | 400 | 0.04 ± 0.01 | [10, 41, 82, 167, 185] | ||
| CCL8/MCP2 | No | ||||||||
| CCL7/MCP3 | No | ||||||||
| CCL13/MCP4 | No | ||||||||
| CCL11/Eotaxin | Yes | ↓ | Gly-Pro▼Ala | 8364.90 | 30 | 0.08 ± 0.01 | [10, 41, 82, 166, 167, 185] | ||
| CCL14a/HCC-1[9–74] | Yes | ↓ | Gly-Pro▼Tyr | 7800.83 | n.d. | n.d. | [188] | ||
| CCL16 | No | ||||||||
| CCL23/MPIF-1 | No | ||||||||
| CXCR3A | CXCL9/Mig | Yes | ↓, CXCR3 antagonist | Thr-Pro▼Val | 11724.81 | 24 | >0.4 ± 0.2 | [82, 166, 167, 185] | |
| CXCL10/IP-10 | Yes | ↓, CXCR3 antagonist | Val-Pro▼Leu | 8646.30 | 4 | 0.5 ± 1 | [10, 41, 82, 166, 167, 185] | ||
| CXCL11/I-TAC | Yes | ↓, CXCR3 antagonist | Phe-Pro▼Met | 8307.01 | 2 | 1.2 ± 0.1 | [82, 166, 167, 185] | ||
|
TH17 (RORγT, CD26+++) |
CCR4 | CCL17/TARC | No | ||||||
| CCL22/MDC | Yes | ↓, RP | Gly-Pro▼Tyr | 8090.47 | 1.6 | 4 ± 1 | [10, 41, 82, 166, 167, 185] | ||
| CCR6 | CCL20/MIP-3α | No | |||||||
CCR C–C motif chemokine receptor, CXCR C–X–C motif chemokine receptor, CCL C–C motif chemokine ligand, CXCL C–X–C motif chemokine ligand, TARC thymus and activation-regulated chemokine, MDC macrophage-derived chemokine, MIP-3α macrophage inflammatory protein-3 α, RANTES regulated on activation, normal T cell expressed and secreted, MCP(2, 3 and 4) monocyte chemotactic protein, MIP5 macrophage inflammatory protein 5, MEC mucosae-associated epithelial chemokine, SDF-1α stromal cell-derived factor 1 α, MIP-1β macrophage inflammatory protein-1β, MPIF-1 myeloid progenitor inhibitory factor 1, Mig monokine induced by γ-interferon, IP-10 10-kDa interferon γ-induced protein, I-TAC interferon-inducible T-cell α chemoattractant, RP change in receptor preference, ↓↑ change in activity/function, n.d not determined