Table 1.

Steps of recruitment, data collection (steps A-G), and analysis (steps 1-5).

Protocol steps	Research activity
A (data collection)	Recruit stakeholders and perform focus group interviews (two sessions)
B (data collection)	Recruit patients
C (data collection)	Collect post-serious gaming feedback from professional and patient users
D (data collection)	Purposively select patients for semistructured interviews
E (data collection)	Perform semistructured interviews with patients
F (data collection)	Perform stakeholder focus group interview (third session)
1 (analysis)	In iteration with steps E and F: Code intervention (I), context (C), mechanism (M), and outcome (O) elements in all the qualitative information Describe ICMO relationships per individual patient interview Compare patient-level findings with focus group data collected from other stakeholders
2 (analysis)	Interpret mechanisms on the basis of formal theory (ie, adjudication) Formulate quantitatively testable hypotheses before outcome inspection
G (data collection)	Retrieve quantitative data from patient records
3 (analysis)	Describe quantitative data as a means to triangulate the qualitative results
4 (analysis)	Test hypotheses with statistical models
5 (analysis)	Mix the results of different methods: summarize how they are interpreted to support, refute, refine, or extend initial expectations Construct summary ICMO configurations (middle-range theory) based on findings of this study Propose a transferable program theory after comparison of findings from this study with those of previous studies